Branchio-oto-facial Syndrome (BOF)
This is a very rare birth defect that is characterized by low birth weight; an abnormal pit, opening, or skin abnormality behind both ears; distinctive malformations of the head and facial area; abnormalities of the eyes; and premature graying of the scalp hair in adolescence. Some people with the syndrome may have a cleft palate or cleft lip. Other problems can include a broad, misshapen nose and malformed ears. Eye problems may include unusually small size, clouding of the lenses, crossing, wide spacing, and an absence of tissue from the colored portion of the eye.